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KMID : 0043320030260110912
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Archives of Pharmacal Research
2003 Volume.26 No. 11 p.912 ~ p.916
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Triterpenoids from Schisandra henryi with Cytotoxic Effect on Leukemia and Hela Cells In Vitro
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Chen Ye-Gao
Wu Zheng-Cai
Lv Yu-Ping
Gui Shi-Hong
Wen Jin
Liao Xin-Rong
Yuan Li-Ming
Halaweish Fathi
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Abstract
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Four known lanostane triterpenoids, schiprolactone A (1), schisanlactone B (2), nigranoic acid (3) and schisandronic acid (4) Were isolated from the stems of Schisandra henryi for the first time. Their structures were characterized by IR, MS and NMR techniques. Compounds 1, 2 and 4 showed moderate cytotoxic activity against Leukemia cells in vitro. Cytotoxic activity of compounds 1-4 showed of 0.0097, 0.01, 0.097 and 0.0099 mol/mL respectively toward Leukemia cells and of 0.097, 0.1, 0.097 and 0.099 mol/mL toward Hela cells respectively. It is the first report that these compounds possess cytotoxic activity on Leukemia and Hela cells.
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KEYWORD
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Schisandra henryi, Triterpenoids, Cytotoxic, Schiprolactone A, Schisanlactone B, Schisandronic acid
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